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Non-obese diabetic or NOD mice, like the Biobreeding rat, are used as an animal model for type 1 diabetes.〔(【引用サイトリンク】 work=National Institute of Allergy and Infectious Diseases )〕 Diabetes develops in NOD mice as a result of insulitis, a leukocytic infiltrate of the pancreatic islets.〔 Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity. 1997; 7:727-38. PMID 9430219〕 Onset of diabetes is associated with a moderate glycosuria and a non-fasting hyperglycaemia. It is recommended to monitor for development of glycosuria from 10 weeks of age; this can be carried out using urine glucose dipsticks. NOD mice will develop spontaneous diabetes when left in a sterile environment. 〔Eisenbarth, GS. Type 1 Diabetes: Molecular Cellular and Clinical Immunology. 2004; 552〕 The incidence of spontaneous diabetes in the NOD mouse is 60-80% in females and 20-30% in males. Onset of diabetes also varies between males and females: commonly, onset is delayed in males by several weeks. == History == Non-obese diabetic (NOD) mice exhibit a susceptibility to spontaneous development of autoimmune insulin dependent diabetes mellitus (IDDM). The NOD strain and related strains were developed at Shionogi Research Laboratories in Aburahi, Japan by Makino and colleagues and first reported in 1980. The group developed the NOD strain by an outbreeding of the cataract-prone strain from JcI:ICR mice. 〔 〕 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「NOD mice」の詳細全文を読む スポンサード リンク
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